Romanian draughtsman, caricaturist, and painter, Constantin Jiquidi came of age in Iași in a milieu directly connected to the literary and artistic circles of the late nineteenth century. His early formation unfolded in proximity to figures such as Eminescu, Caragiale, and Creangă, a cultural environment that shaped both the satirical intelligence and the range of his graphic output. He debuted at seventeen with Tipuri din Iași (Types from Iași), followed by collaboration with the Iași humor magazine Bobârnacul, and achieved early critical recognition with the first volume of his Caricaturi (Caricatures) album in 1889.

After settling in Bucharest that same year, Jiquidi became a central figure in the illustrated press of the period. His most significant editorial collaboration was with Ion Luca Caragiale at Moftul Român (The Romanian Trifle), the satirical review founded in 1893, in which some of Caragiale's most important sketches appeared alongside Jiquidi's caricatures from issue eleven onward. He also collaborated with Amicul Copiilor (The Children's Friend), where he is credited as likely the first Romanian artist to publish comic strips, in 1893. His colleagues at Moftul Român included Dimitrie Teleor, Emil Gârleanu, Ion Alexandru Brătescu-Voinești, and Alexandru Cazaban.

His practice extended well beyond caricature. Working in oil, gouache, watercolor, and engraving, he organized a major solo exhibition in 1893–1894 comprising some 250 works, followed by further personal exhibitions in 1894 and 1898, participation in the Salon des Indépendants in 1896, and a watercolor and gouache exhibition at the Romanian Athenaeum in 1898, considered by the press of the time among the most significant artistic events of the year.

Jiquidi died in Bucharest at thirty-four, leaving a body of work dispersed across the publications and periodicals of the final decade of the nineteenth century. He was the father of graphic artist Aurel Jiquidi (1896–1962).